Scientific research and publications
Prof. Valero Sanguigni
My scientific work has developed within cardiology and internal medicine, with a particular focus on the mechanisms involved in cardiovascular disease and aging.
Over the years, I have participated in studies on atherosclerosis, oxidative stress, platelet activation and factors that can influence vascular function.
The findings have been published in international scientific journals indexed in PubMed.
View my publications on PubMed
ExploreMain areas of research
Atherosclerosis and cardiovascular risk
Part of my scientific work has focused on the mechanisms that contribute to the development and progression of atherosclerosis.
These studies have examined hypercholesterolemia, carotid atherosclerosis, endothelial dysfunction and other factors associated with cardiovascular risk.
Oxidative stress and vascular function
Oxidative stress is one of the main research areas I have explored.
I have investigated the role of oxygen free radicals and the enzymes involved in their production, with a particular focus on their effects on vascular function and atherosclerotic processes.
Platelet activation and thrombosis
I have devoted particular attention to the mechanisms that regulate platelet activation and thrombin generation.
This research has contributed to the study of the relationships among oxidative stress, inflammation, platelet function and cardiovascular disease.
Medications, nutrition and modifiable factors
My scientific work has also examined the effects of certain drug treatments and specific dietary components on cardiovascular mechanisms.
Topics investigated include the effects of statins, metformin and certain antihypertensive medications, as well as the role of polyphenols and antioxidant foods in vascular function and physical performance.
Observing a phenomenon, asking a question, collecting data and verifying what the findings mean: scientific research requires a method and a willingness to reconsider one's hypotheses.
I apply the same approach to cardiovascular prevention and longevity: starting with the available evidence and distinguishing what has been demonstrated from what still needs further investigation.
Cardiovascular Prevention
Find outLongevity
Find outValerio Sanguigni: scientific publications
Inappropriate Sinus Tachycardia in Athletes: Could Nutraceuticals Play a Role?
Scarà A, Borrelli A, Robles AG, Burazor S, Dei LL, Zanin F, Pignalosa L, Cavarretta E, Fusco L, Pernat A, Sanguigni V, Romano S, Sciarra L.
J Cardiovasc Dev Dis. 2025 Feb 15;12(2):73. doi: 10.3390/jcdd12020073.PMID: 39997507
New Insight into Molecular and Hormonal Connection in Andrology
Francomano D, Sanguigni V, Capogrosso P, Deho F, Antonini G.
Int J Mol Sci. 2021 Nov 2;22(21):11908. doi: 10.3390/ijms222111908.PMID: 34769341 . Review
The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors
Cammisotto V, Nocella C, Bartimoccia S, Sanguigni V, Francomano D, Sciarretta S, Pastori D, Peruzzi M, Cavarretta E, D’Amico A, Castellani V, Frati G, Carnevale R, Group S.
Antioxidants (Basel). 2021 Jan 20;10(2):146. doi: 10.3390/antiox10020146
A novel role of MMP2 in regulating platelet NOX2 activation
Nocella C, Cammisotto V, Bartimoccia S, Castellani V, Loffredo L, Pastori D, Pignatelli P, Sanguigni V, Violi F, Carnevale R.
Free Radic Biol Med. 2020 May 20;152:355-362. doi: 10.1016/j.Free Rad biomed.2020.03.033. Epub 2020 Apr 5.PMID: 32268176
Impaired platelet activation in patients withhereditary deficiency of p47phox.
Carnevale R., Loffredo L., Nocella C., Bartimoccia S., Sanguigni V., Soresina A., Plebani A., Azzari C., Martire B., Pignata C., Violi F. (2018).
British Journal of Haematology, ISSN: 1365-2141
Natural antioxidant ice cream acutely reduces oxidative stress and improves vascular function and physical performance in healthy individuals.
Sanguigni V., Manco M., Sorge R., Gnessi L., Francomano D. (2017).
Nutrition, ISSN: 0899-9007
NOX 5 is expressed in platelets frompatients with chronic granulomatous disease.
Bartimoccia S., Carnevale R., Sanguigni V., De Falco E., Frati G., Loffredo L., Plebani A., Soresina A., Pignatelli P., Violi F. (2016).
Thrombosis and haemostasis, ISSN: 0340-6245
Different degrees of NADPH oxidase 2 regulation and in vivo platelet activation: lesson from chronic granulomatous disease.
Carnevale R., Loffredo L., Sanguigni V., Plebani A., Rossi P., Pignata C., Martire B., Finocchi A., Pietrogrande M., Azzari C., Soresina A., Martino S., Cirillo E., Martino F., Pignatelli P., Violi F. (2014).
Journal of the american heart association.
Cardiovascular and cerebrovascular disease, vol. 3, p. e000920, ISSN: 2047-9980, doi: 10.1161/JAHA.114.000920
