Scientific research and publications

Prof. Valero Sanguigni

My scientific work has developed within cardiology and internal medicine, with a particular focus on the mechanisms involved in cardiovascular disease and aging.

Over the years, I have participated in studies on atherosclerosis, oxidative stress, platelet activation and factors that can influence vascular function.

The findings have been published in international scientific journals indexed in PubMed.

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Main areas of research

Atherosclerosis and cardiovascular risk

Part of my scientific work has focused on the mechanisms that contribute to the development and progression of atherosclerosis.

These studies have examined hypercholesterolemia, carotid atherosclerosis, endothelial dysfunction and other factors associated with cardiovascular risk.

Oxidative stress and vascular function

Oxidative stress is one of the main research areas I have explored.

I have investigated the role of oxygen free radicals and the enzymes involved in their production, with a particular focus on their effects on vascular function and atherosclerotic processes.

Platelet activation and thrombosis

I have devoted particular attention to the mechanisms that regulate platelet activation and thrombin generation.

This research has contributed to the study of the relationships among oxidative stress, inflammation, platelet function and cardiovascular disease.

Medications, nutrition and modifiable factors

My scientific work has also examined the effects of certain drug treatments and specific dietary components on cardiovascular mechanisms.

Topics investigated include the effects of statins, metformin and certain antihypertensive medications, as well as the role of polyphenols and antioxidant foods in vascular function and physical performance.

Observing a phenomenon, asking a question, collecting data and verifying what the findings mean: scientific research requires a method and a willingness to reconsider one's hypotheses.

I apply the same approach to cardiovascular prevention and longevity: starting with the available evidence and distinguishing what has been demonstrated from what still needs further investigation.

Cardiovascular Prevention

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Longevity

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Valerio Sanguigni: scientific publications

Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress.

Violi F., Pignatelli P., Pignata C., Plebani A., Rossi P., Sanguigni V., Carnevale R., Soresina A., Finocchi A., Cirillo E., Catasca E., Angelico F., Loffredo L. (2013).

Arteriosclerosis, thrombosis, and vascular biology, vol. 33, p. 406-412, ISSN: 1079-5642, doi: 10.1161/ATVBAHA.112.300438

Does NADPH oxidase deficiency cause artery dilatation in humans?

Loffredo L., Carnevale R., Sanguigni V., Plebani A., Rossi P., Pignata C., De Mattia D., Finocchi A., Martire B., Pietrogrande M.C., Martino S., Gambineri E., Giardino G., Soresina A.R., Martino F., Pignatelli P., Violi F. (2013).

Antioxidants & redox signaling, ISSN: 1523-0864, doi: 10.1089/ars.2012.4987

Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction.

Pignatelli P., Carnevale R., Di Santo S., Bartimoccia S., Sanguigni V., Lenti L., Finocchi A., Mendolicchio L., Soresina A., Plebani A., Violi F. (2011).

Arteriosclerosis, thrombosis, and vascular biology, vol. 31, p. 423-434, ISSN: 1079-5642, doi: 10.1161/ATVBAHA.110.217885

Atorvastatin inhibits oxidative stress via adiponectin-mediated NADPH oxidase down-regulation in hypercholesterolemic patients.

Carnevale R, Pignatelli P, Di Santo S, Bartimoccia S, Sanguigni V, Napoleone L, Tanzilli G, Basili S, Violi F. (2010).

Atherosclerosis, ISSN: 0021-9150, doi: 10.1016/j.atherosclerosis.2010.08.056.

Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia.

Pignatelli P, Carnevale R, Cangemi R, Loffredo L, Sanguigni V, Stefanutti C, Basili S, Violi F (2010).

Arteriosclerosis, thrombosis, and vascular biology, vol. 30, p. 360-367, ISSN: 1079-5642, doi: 10.1161/ATVBAHA.109.198622

Hereditary Deficiency of gp91(phox) Is Associated With Enhanced Arterial Dilatation Results of a Multicenter Study.

Violi F, Sanguigni V, Carnevale R, Plebani A, Rossi P, Finocchi A, Pignata C, De Mattia D, Martire B, Pietrogrande MC, Martino S, Gambineri E, Soresina AR, Pignatelli P, Martino F, Basili S, Loffredo L (2009).

Circulation, vol. 120, p. 1616-1622, ISSN: 0009-7322, doi: 10.1161/CIRCULATIONAHA.109.877191

Oxidative stress is associated with arterial dysfunction and enhanced intima-media thickness in children with hypercholesterolemia: the potential role ofnicotinamide-adenine dinucleotide phosphate oxidase.

Martino F, Loffredo L, Carnevale R, Sanguigni V, Martino E, Catasca E, Zanoni C, Pignatelli P, Violi F (2008).

Pediatrics, vol. 122, p. 648-655, ISSN: 0079-0400, doi: 10.1542/peds.2008-0735.

Early decrease of oxidative stress by atorvastatin in hypercholesterolaemic patients: effect on circulating vitamin E.

Cangemi R, Loffredo L, Carnevale R, Perri L, Patrizi MP, Sanguigni V, Pignatelli P, Violi F (2008).

European Heart Journal, vol. 29, p. 54-62, ISSN: 0195-668X, doi: 10.1093/eurheartj/ehm565