Scientific research and publications

Prof. Valero Sanguigni

My scientific work has developed within cardiology and internal medicine, with a particular focus on the mechanisms involved in cardiovascular disease and aging.

Over the years, I have participated in studies on atherosclerosis, oxidative stress, platelet activation and factors that can influence vascular function.

The findings have been published in international scientific journals indexed in PubMed.

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Main areas of research

Atherosclerosis and cardiovascular risk

Part of my scientific work has focused on the mechanisms that contribute to the development and progression of atherosclerosis.

These studies have examined hypercholesterolemia, carotid atherosclerosis, endothelial dysfunction and other factors associated with cardiovascular risk.

Oxidative stress and vascular function

Oxidative stress is one of the main research areas I have explored.

I have investigated the role of oxygen free radicals and the enzymes involved in their production, with a particular focus on their effects on vascular function and atherosclerotic processes.

Platelet activation and thrombosis

I have devoted particular attention to the mechanisms that regulate platelet activation and thrombin generation.

This research has contributed to the study of the relationships among oxidative stress, inflammation, platelet function and cardiovascular disease.

Medications, nutrition and modifiable factors

My scientific work has also examined the effects of certain drug treatments and specific dietary components on cardiovascular mechanisms.

Topics investigated include the effects of statins, metformin and certain antihypertensive medications, as well as the role of polyphenols and antioxidant foods in vascular function and physical performance.

Observing a phenomenon, asking a question, collecting data and verifying what the findings mean: scientific research requires a method and a willingness to reconsider one's hypotheses.

I apply the same approach to cardiovascular prevention and longevity: starting with the available evidence and distinguishing what has been demonstrated from what still needs further investigation.

Cardiovascular Prevention

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Longevity

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Valerio Sanguigni: scientific publications

Oxidative stress-mediated platelet CD40 ligand upregulation in patients with hypercholesterolemia: effect of atorvastatin.

Pignatelli P, Sanguigni V, Lenti L, Loffredo L, Carnevale R, Sorge R, Violi F (2007).

Journal of thrombosis and haemostasis, vol. 5, p. 1170-1178, ISSN: 1538-7933, doi: 10.1111/j.1538-7836.2007.02533

LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes.

Carnevale R, Pignatelli P, Lenti L, Buchetti B, Sanguigni V, Di Santo S, Violi F (2007).

The Faseb Journal, vol. 21, p. 927-934, ISSN: 0892-6638, doi: 10.1096/fj.06-6908com

Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment.

Pignatelli P, Di Santo S, Buchetti B, Sanguigni V, Brunelli A, Violi F (2006).

Faseb Journal, vol. 20, p. 1082-1089, ISSN: 0892-6638

Nox2 is determinant for ischemia-induced oxidative stress and arterial vasodilatation: a pilot study in patients with hereditary Nox2 deficiency.

Violi F, Sanguigni V, Loffredo L, Carnevale R, Buchetti B, Finocchi A, Tesauro M, Rossi P, Pignatelli P (2006).

Arteriosclerosis, thrombosis, and vascular biology, vol. 26, ISSN: 1079-5642, doi: 10.1161/01.ATV.0000229710.13054.2d

Vitamin C inhibits platelet expression of CD40 ligand

Pignatelli P, Sanguigni V, Paola SG, Lo Coco E, Lenti L, Violi F (2005).

Free radical biology & medicine, vol. 38, p. 1662-1666, ISSN: 0891-5849, doi: 10.1016/j.freeradbiomed.2005.02.032

Short-term treatment with atorvastatin reduces platelet CD40 ligand and thrombin generation in hypercholesterolemic patients.

Sanguigni V, Pignatelli P, Lenti L, Ferro D, Bellia A, Carnevale R, Tesauro M, Sorge R, Lauro R, Violi F (2005).

Circulation, vol. 111, p. 412-419, ISSN: 0009-7322, doi: 10.1161/01.CIR.0000153810.81187.7D

Early anticoagulant effect of atorvastatin.

Pignatelli P, Sanguigni V, Buchetti B, Lenti L, Violi (2005).

Arteriosclerosis, thrombosis, and vascular biology, vol. 25, p. e 145-e 145, ISSN: 1079-5642

CD40 ligand enhances monocyte tissue factor expression and thrombin generation via oxidative stress in patients with hypercholesterolemia.

Sanguigni V, Ferro D, Pignatelli P, Del Ben M, Nadia T, Saliola M, Sorge R, Violi F (2005).

Journal of the american college of cardiology, vol. 45, p. 35-42, ISSN: 0735-1097, doi: 10.1016/j.jacc.2004.09.047